Progesterone's role in breast cancer development through immune system effects
Progesterone promotes mammary gland tumorigenesis through immunosuppressive effects on dendritic cells
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-11094763
This study is looking at how the hormone progesterone might help breast cancer grow by affecting certain immune cells in the breast, and it aims to find new ways to improve treatment for patients.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-11094763 on ClinicalTrials.gov |
What this research studies
This research investigates how progesterone, a hormone, influences the development of breast cancer by affecting immune cells called dendritic cells in the mammary gland. The study aims to understand the mechanisms by which progesterone promotes tumor growth and immune suppression. By examining how progesterone interacts with immune signaling pathways, the researchers hope to uncover new insights into breast cancer progression. This could lead to potential therapeutic strategies targeting these pathways to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are women who have been exposed to synthetic progesterone and are at risk for developing breast cancer.
Not a fit: Patients who have not been exposed to progesterone or who do not have a history of breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce the risk of breast cancer in women exposed to progesterone.
How similar studies have performed: Previous research has shown that hormonal influences can significantly impact breast cancer development, suggesting that this approach may yield valuable insights.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WERNER, LAURYN ROSE — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: WERNER, LAURYN ROSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Cell, cancer antigens