Profiling sugars in the brain and blood related to Alzheimer's disease
Official title: Brain and blood N-glycome profiling in Alzheimer's disease
Funded at University of South Florida · NIH-11321443 · Data updated 2026-11-12
This study is looking at how certain sugars attached to proteins might be linked to Alzheimer's disease, and it aims to find new markers in the brain and blood that could help us understand the disease better and track its progression in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $756,427 |
| NIH project number | 7R01AG085469-02 |
| Project ID | NIH-11321443 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease, such as older adults or those with a family history of dementia.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of N-glycosylation, a process where sugars are added to proteins, in Alzheimer's disease (AD). By analyzing the complete repertoire of N-glycans in both brain and blood samples, the study aims to identify potential biomarkers for AD and understand how changes in these sugars may contribute to the disease's progression. The research will involve large-scale human populations to gather comprehensive data on how these sugar modifications relate to AD pathology and cognitive decline.
Why it matters
Potential benefit: If successful, this research could lead to the development of reliable biomarkers for early detection and monitoring of Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in identifying biomarkers related to Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Zhao, Jinying — University of South Florida
- Study coordinator: Zhao, Jinying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.