Profiling DNA, RNA, and proteins in individual cells to study Alzheimer's disease
Official title: Single cell tri-omics: High coverage simultaneous profiling of DNA, RNA, and proteins in single cells
Funded at Fluid Discovery INC · NIH-10821171 · Data updated 2026-11-12
This study is testing a new technology that helps scientists look at DNA, RNA, and proteins in single brain cells to better understand Alzheimer's disease, and it's designed to help researchers learn more about how these cells work.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fluid Discovery INC NIH-funded |
| Lab location | 1 site (San Francisco, UNITED STATES) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $268,142 |
| NIH project number | 1R43NS135703-01 |
| Project ID | NIH-10821171 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-neurological conditions or those without a diagnosis of dementia may not benefit from this research.
What this research studies
This research focuses on developing a new technology called Self-Assembled Partitioning Proteomics (SAP-pm) that allows for the simultaneous analysis of DNA, RNA, and proteins in single cells. By using advanced techniques in microfluidics and biophysics, the project aims to quantify thousands of proteins in hundreds of thousands of individual cells, providing a comprehensive view of cellular functions. This approach will help researchers gain valuable insights into Alzheimer's disease by analyzing brain nuclei and capturing mRNA from primary human tissues.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using single-cell analysis techniques for understanding complex diseases, indicating that this approach could yield significant insights.
Where this research is happening
-
Fluid Discovery INC
San Francisco, United States Active
Researchers
- Principal investigator: Prince, Robin — Fluid Discovery INC
- Study coordinator: Prince, Robin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.