Preventing vision loss from herpes virus infections in the eye.
Targeting anti-viral and anti-inflammatory responses during ocular HSV-1 infection to prevent vision impairment.
This study is looking at new ways to help people with stromal keratitis, a painful eye condition caused by the herpes virus, by boosting the body's natural defenses to fight the virus and reduce inflammation, which could help prevent vision problems.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project ID | NIH-10651054 on NIH RePORTER |
What this research studies
This research focuses on developing new treatments for stromal keratitis, a painful eye condition caused by recurrent herpes simplex virus-1 (HSV-1) infections. The approach aims to enhance the body's natural anti-viral and anti-inflammatory responses by targeting a specific immune molecule called IL-27. By doing so, the researchers hope to reduce the severity of the infection and inflammation, ultimately preventing vision impairment. The study will involve laboratory experiments to understand how IL-27 can help control the virus and improve healing in the cornea.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing recurrent herpes simplex virus infections that lead to keratitis and vision problems.
Not a fit: Patients who do not have HSV-1 infections or those with other unrelated eye conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from vision impairment due to HSV-1 infections.
How similar studies have performed: Previous research has shown promise in using immunotherapy approaches to enhance anti-viral responses, suggesting potential success for this novel strategy.
Where this research is happening
Auburn, UNITED STATES
- Auburn University at Auburn — Auburn, United States (Active)
Researchers
- Principal investigator: Ramapuram, Jayachandra B — Auburn University at Auburn
- Study coordinator: Ramapuram, Jayachandra B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.