Preventing the spread of Hepatitis B from mothers to infants in Africa
Reducing Vertical Transmission of Hepatitis B in Africa (REVERT-B Trial)
This study is looking for ways to help pregnant women in Africa who have Hepatitis B protect their babies from getting the virus, by testing new treatments and vaccination methods to keep both moms and their newborns healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10808129 on NIH RePORTER |
What this research studies
This research focuses on addressing the high rates of Hepatitis B virus (HBV) transmission from pregnant women to their infants in Africa. Many women are unaware of their HBV status, which puts their newborns at significant risk of developing chronic infections. The study aims to explore innovative interventions, including the use of antiviral therapies, to effectively reduce HBV viral load and improve vaccination strategies at birth. By conducting a multicenter clinical trial, the research seeks to identify safe and practical methods to prevent perinatal transmission of HBV.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women in Sub-Saharan Africa who are at risk of HBV infection.
Not a fit: Patients who are not pregnant or those who are not at risk of HBV infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of chronic Hepatitis B infections in infants, leading to better long-term health outcomes.
How similar studies have performed: Previous studies in Asia have shown success with antiviral therapies in reducing HBV transmission, suggesting potential for similar outcomes in this research.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Dionne, Jodie Ann — University of Alabama at Birmingham
- Study coordinator: Dionne, Jodie Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.