Preventing the progression of a precancerous blood condition called MGUS
Official title: Cancer Prevention-Interception Against MGUS Progression
Funded at Baylor College of Medicine · NIH-10910167 · Data updated 2026-11-12
This study is looking at how to help people with MGUS, a condition that can lead to cancer, by finding out what causes it to get worse and creating better ways to prevent cancer from developing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,078,336 |
| NIH project number | 5U54CA272691-02 |
| Project ID | NIH-10910167 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with monoclonal gammopathy of undetermined significance (MGUS).
✕Less likely to help
Patients without a diagnosis of MGUS or those with advanced cancer may not benefit from this research.
What this research studies
This research focuses on monoclonal gammopathy of undetermined significance (MGUS), a condition where patients have elevated levels of an abnormal protein in their blood, increasing their risk of developing various cancers. The project aims to identify cancer-driving molecules and the bone marrow environment that contribute to the progression of MGUS into more severe conditions. By establishing a specialized center, the research will facilitate collaborative efforts to develop targeted prevention strategies for patients with MGUS. Patients with this condition will be monitored and potentially treated to prevent the onset of cancer.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of cancer in patients with MGUS.
How similar studies have gone: Previous research has shown promise in targeting precancerous conditions, indicating potential for success in this novel approach.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Li, Yong — Baylor College of Medicine
- Study coordinator: Li, Yong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.