Preventing sudden death in epilepsy using milk whey
Prevention of SUDEP by milk whey: Role of CO2 chemoreception and serotonin
This study is looking at how seizures can sometimes cause serious breathing problems in people with epilepsy, and it's exploring whether a diet high in milk whey can help by boosting serotonin levels to lower the risk of sudden unexpected death in epilepsy (SUDEP).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11098624 on NIH RePORTER |
What this research studies
This research investigates how seizures can lead to fatal respiratory arrest in patients with epilepsy, particularly focusing on the role of serotonin and CO2 chemoreception. By studying genetic mouse models that mimic human epilepsy, the researchers aim to understand the mechanisms that increase the risk of sudden unexpected death in epilepsy (SUDEP). They have found that a diet enriched with milk whey may help reduce this risk by potentially enhancing serotonin levels. The study will explore the relationship between seizures, breathing regulation, and dietary interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with refractory epilepsy who are at risk for SUDEP.
Not a fit: Patients with well-controlled epilepsy or those not at risk for SUDEP may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of sudden unexpected death in patients with epilepsy.
How similar studies have performed: Previous research has indicated that dietary interventions can influence serotonin levels and potentially improve seizure outcomes, suggesting a promising avenue for this approach.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Richerson, George B — University of Iowa
- Study coordinator: Richerson, George B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.