Preventing strokes in children with sickle cell anemia in Nigeria
Official title: Stroke Prevention in Nigeria: SPRING 2
Funded at Vanderbilt University Medical Center · NIH-10994102 · Data updated 2026-11-12
This study is looking at how well hydroxyurea can help prevent strokes in children with sickle cell anemia in Nigeria, and it's for kids who might be at risk due to their blood flow.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $116,949 |
| NIH project number | 3U01NS129143-01A1S1 |
| Project ID | NIH-10994102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21 years diagnosed with sickle cell anemia and exhibiting abnormal transcranial Doppler velocities.
✕Less likely to help
Patients who do not have sickle cell anemia or those without abnormal transcranial Doppler velocities may not benefit from this research.
What this research studies
This research investigates the effectiveness of hydroxyurea therapy for preventing strokes in children with sickle cell anemia living in Nigeria. It builds on previous findings from a randomized controlled trial that compared different doses of hydroxyurea and their impact on stroke incidence and hospitalizations. The study will involve multiple centers and aims to confirm that hydroxyurea can effectively reduce stroke risk in children with abnormal blood flow velocities. Participants will be monitored for stroke events and other health outcomes over the course of the trial.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of strokes in children with sickle cell anemia, improving their overall health and quality of life.
How similar studies have gone: Previous studies have shown promising results with hydroxyurea therapy in reducing stroke risk in similar populations, indicating that this approach has potential for success.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Debaun, Michael R. — Vanderbilt University Medical Center
- Study coordinator: Debaun, Michael R.
Related research
Other NIH-funded projects on the same topics.
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Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
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Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
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LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
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BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.