Preventing sepsis-related deaths in children
Official title: Suspect Treat Organ failure Prevent Sepsis Mortality (STOP Sepsis Mortality)
Funded at Children's Research Institute · NIH-11020157 · Data updated 2026-11-12
This study is looking at how to better diagnose and treat sepsis in children by understanding how their bodies react to infections, with the goal of finding quick and effective treatments to help save lives.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $455,000 |
| NIH project number | 1R35GM157142-01 |
| Project ID | NIH-11020157 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are at risk of or diagnosed with sepsis.
✕Less likely to help
Patients who are not within the pediatric age range or those with conditions unrelated to sepsis may not benefit from this research.
What this research studies
This research focuses on improving the diagnosis and treatment of pediatric sepsis, a severe condition that can lead to organ failure and death in children. It aims to understand the different ways sepsis can present in young patients and how their immune systems respond to infections. By utilizing advanced techniques, including artificial intelligence and studying cellular energy processes, the research seeks to identify effective treatments that can be administered quickly to save lives. The project will also explore the role of mesenchymal stem cells in enhancing cellular energy and reducing inflammation.
Why it matters
Potential benefit: If successful, this research could significantly reduce the mortality rate of sepsis in children, particularly in underserved populations.
How similar studies have gone: Previous research has shown promise in improving sepsis outcomes through innovative treatment approaches, but this specific focus on pediatric populations and the use of AI is relatively novel.
Where this research is happening
-
Children's Research Institute
Washington, United States Active
Researchers
- Principal investigator: Koutroulis, Ioannis — Children's Research Institute
- Study coordinator: Koutroulis, Ioannis
Related research
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This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
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Sepsis patient care guided by Ugandan-wide immune profiling
A large NIH-funded study will map how the immune system behaves during sepsis in people in Uganda to improve personalized care for sepsis patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.