Preventing opioid use disorder before it starts

SUBTHRESHOLD OPIOID USE DISORDER PREVENTION TRIAL (CTN-0101). AUGUST 1, 2024 TO MARCH 31, 2026. N01DA-22-2253. TASK ORDER NO. 75N95024F00004 (TO20).

NIH-funded research The Emmes Company, LLC · NIH-11211246

This study is looking for ways to help people who are at risk of developing problems with opioid use, and it offers support and strategies to keep them safe from addiction.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionThe Emmes Company, LLC NIH-funded
Lab location1 site (Rockville, United States)
Project IDNIH-11211246 on NIH RePORTER

What this research studies

This research focuses on developing and testing strategies to prevent opioid use disorder among individuals at risk. It is part of the NIH's HEAL initiative, which aims to address the opioid crisis by finding effective solutions for opioid misuse and addiction. The trial will involve various interventions designed to reduce the likelihood of developing an opioid use disorder, with a focus on non-medical opioid use. Patients may participate in assessments and receive support tailored to their needs during the trial period.

Who could benefit from this research

Good fit: Ideal candidates for participation are individuals at risk of developing opioid use disorder, particularly those with a history of non-medical opioid use.

Not a fit: Patients who are already diagnosed with opioid use disorder may not benefit from this prevention-focused research.

Why it matters

Potential benefit: If successful, this research could significantly reduce the incidence of opioid use disorder and improve public health outcomes.

How similar studies have performed: Previous research within the HEAL initiative has shown promise in developing effective strategies for addressing opioid misuse, indicating a potential for success in this area.

Where this research is happening

Rockville, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.