Preventing muscle loss by understanding cell interactions
Modulating Fibro/Adipogenic Precursors to Prevent Adipogenic Replacement of Muscle
This study is looking at how different types of cells work together to help muscles heal and what goes wrong in conditions like muscular dystrophy, with the goal of finding new treatments to slow down muscle loss.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11089302 on NIH RePORTER |
What this research studies
This research investigates how different cell populations interact during muscle regeneration and what happens when these interactions are disrupted, particularly in conditions like muscular dystrophy. The focus is on understanding the mechanisms that lead to muscle degeneration and the replacement of muscle fibers with fat or fibrous tissue. By studying these processes, the research aims to develop new therapies that can halt the progression of muscular dystrophies, which currently have limited treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with limb girdle muscular dystrophy type 2B or similar muscular dystrophies.
Not a fit: Patients with muscle degeneration due to causes unrelated to muscular dystrophies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent muscle loss and improve quality of life for patients with muscular dystrophies.
How similar studies have performed: While the specific approach may be novel, there is a growing body of research exploring cellular interactions in muscle regeneration, indicating potential for success.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Hogarth, Marshall — Children's Research Institute
- Study coordinator: Hogarth, Marshall
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.