Preventing liver failure in patients with cirrhosis
Prediction and Prevention of Hepatic Decompensation in Patients with Cirrhosis
This study is looking at ways to help people with cirrhosis, a liver condition, by finding out what factors can be changed to prevent liver failure and testing if a specific medication, a statin, can help keep their liver healthy over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10909145 on NIH RePORTER |
What this research studies
This research focuses on understanding and preventing liver failure in patients suffering from cirrhosis. It aims to identify modifiable risk factors that contribute to liver dysfunction and how this dysfunction affects other organs. The study will involve a longitudinal cohort of cirrhosis patients and will test the effectiveness of a specific medication, a statin, in preventing liver decompensation in those at high risk. Patients will be monitored over time to gather data on their liver function and overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with cirrhosis, particularly those at high risk for liver failure.
Not a fit: Patients with cirrhosis who are not at risk for hepatic decompensation or those with other terminal conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving liver function and improving the quality of life for patients with cirrhosis.
How similar studies have performed: Previous research has shown promise in using statins for liver-related conditions, suggesting potential success for this approach.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Moylan, Cynthia a — Duke University
- Study coordinator: Moylan, Cynthia a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.