Preventing HIV in people who use methamphetamine

PRIME: PrEP Intervention for people who Inject MEthamphetamine

NIH-funded research Public Health Foundation Enterprises · NIH-10877124

This study is looking for people who inject methamphetamine to try out a new way to help them stick to taking a medication called PrEP, which can prevent HIV, so we can see if it helps keep them healthier.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionPublic Health Foundation Enterprises NIH-funded
Lab location1 site (City of Industry, United States)
Project IDNIH-10877124 on NIH RePORTER

What this research studies

This research focuses on developing and testing a pre-exposure prophylaxis (PrEP) intervention specifically for individuals who inject methamphetamine. It aims to address the rising rates of HIV infections in this population by improving medication adherence to PrEP, which is a highly effective preventive measure against HIV. The study will utilize a two-arm trial design to evaluate the effectiveness of the intervention, which may include the use of mobile applications to support adherence. Participants will be actively followed to assess their health outcomes and adherence to the PrEP regimen.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults aged 21 and older who inject methamphetamine and are at risk for HIV.

Not a fit: Patients who do not inject drugs or those who are not at risk for HIV may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly reduce new HIV infections among people who inject methamphetamine.

How similar studies have performed: While there has been limited research specifically targeting this population, similar approaches in other high-risk groups have shown promise in improving adherence to HIV prevention strategies.

Where this research is happening

City of Industry, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.