Preventing HIV in people who use methamphetamine
Official title: PRIME: PrEP Intervention for people who Inject MEthamphetamine
Funded at Public Health Foundation Enterprises · NIH-10877124 · Data updated 2026-11-12
This study is looking for people who inject methamphetamine to try out a new way to help them stick to taking a medication called PrEP, which can prevent HIV, so we can see if it helps keep them healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Public Health Foundation Enterprises NIH-funded |
| Lab location | 1 site (City of Industry, United States) |
| Project start | August 1, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $738,862 |
| NIH project number | 5R01DA051850-05 |
| Project ID | NIH-10877124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who inject methamphetamine and are at risk for HIV.
✕Less likely to help
Patients who do not inject drugs or those who are not at risk for HIV may not benefit from this research.
What this research studies
This research focuses on developing and testing a pre-exposure prophylaxis (PrEP) intervention specifically for individuals who inject methamphetamine. It aims to address the rising rates of HIV infections in this population by improving medication adherence to PrEP, which is a highly effective preventive measure against HIV. The study will utilize a two-arm trial design to evaluate the effectiveness of the intervention, which may include the use of mobile applications to support adherence. Participants will be actively followed to assess their health outcomes and adherence to the PrEP regimen.
Why it matters
Potential benefit: If successful, this research could significantly reduce new HIV infections among people who inject methamphetamine.
How similar studies have gone: While there has been limited research specifically targeting this population, similar approaches in other high-risk groups have shown promise in improving adherence to HIV prevention strategies.
Where this research is happening
-
Public Health Foundation Enterprises
City of Industry, United States Active
Researchers
- Principal investigator: Coffin, Phillip O — Public Health Foundation Enterprises
- Study coordinator: Coffin, Phillip O
Related research
Other NIH-funded projects on the same topics.
-
mChoice: Boosting PrEP Use and Adherence for Black and Latino MSM with Tailored Training and Support
A national study to help Black and Latino men who have sex with men start and stick with PrEP through culturally matched provider training and patient support.
-
Harnessing male peer networks to boost HIV testing and PrEP use
A large clinical trial in South Africa tests whether giving HIV self-test kits through male peer networks, with phone support, increases PrEP uptake among men.
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Harnessing men's peer networks to boost HIV self-testing and PrEP use
A large project in South Africa tests whether giving HIV self-test kits through men’s social networks, with phone support, can lead to more men starting PrEP and using HIV testing.
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Participatory system dynamics to improve PrEP access in the Bronx
A community-driven project in the Bronx will use system dynamics to identify practical ways to help people at risk for HIV start and stay on PrEP.
-
TB PrEP: Bringing HIV prevention to households affected by TB in Uganda
Aims to help people in households with TB in Uganda access HIV PrEP as part of a combined prevention approach.
-
CARES: A practical program to help adolescent girls and young women use PrEP in Africa
A program called CARES helps young women in South Africa and Zimbabwe use different PrEP options better, with counseling, reminders, and options for support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.