Preventing fretting-corrosion in hip and knee joint implants
Official title: Preclinical Assessment Tools for Preventing Fretting-Corrosion within Modular Junctions of Total Joint Replacement
Funded at Rush University Medical Center · NIH-11408759 · Data updated 2026-11-12
Aims to develop better preclinical tests to predict and prevent fretting-corrosion and related tissue reactions in modular joint implants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 5, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $544,976 |
| NIH project number | 5R01AR084468-02 |
| Project ID | NIH-11408759 on NIH RePORTER |
Who could benefit from this research
✓Could help
No direct patient enrollment is required for the preclinical work, but the findings will guide future patient-facing implant choices and safety standards.
✕Less likely to help
Patients will not participate in this preclinical work; benefits are anticipated in future implant designs and testing.
What this research studies
This project at Rush University Medical Center will study how design features, manufacturing tolerances, and the biological environment influence fretting-corrosion in total joint arthroplasty. Researchers will create testing strategies that mimic real human tissue and inflammation, and explore how surface geometry and alloys affect corrosion risk. The goal is to improve preclinical evaluations so safer, longer-lasting joint implants can be developed for patients requiring hip and knee replacements.
Why it matters
Potential benefit: If successful, the work could lead to safer joint implants with fewer ALTRs and longer-lasting performance.
How similar studies have gone: Previous fretting-corrosion research informs this effort, but current preclinical tests often miss the biological context, making this approach novel.
Where this research is happening
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Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Lundberg, Hannah Jean — Rush University Medical Center
- Study coordinator: Lundberg, Hannah Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.