Preventing endometrial cancer in overweight women while preserving fertility
Official title: Project 3: Primary Prevention and Uterine Preservation in Premenopausal Women with Obesity and Endometrial Hyperplasia/Cancer
Funded at Washington University · NIH-10912620 · Data updated 2026-11-12
This study is looking for ways to help overweight or obese women who are not yet in menopause reduce their risk of endometrial cancer by combining hormone treatment with weight loss strategies, all while keeping their fertility in mind.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 23, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $528,932 |
| NIH project number | 5P50CA265793-02 |
| Project ID | NIH-10912620 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are premenopausal women who are overweight or obese and have been diagnosed with atypical endometrial hyperplasia or are at risk for endometrial cancer.
✕Less likely to help
Patients who are not premenopausal or who do not have obesity-related endometrial conditions may not benefit from this research.
What this research studies
This research investigates how to prevent endometrial cancer in premenopausal women who are overweight or obese by combining progestin treatment with effective weight loss strategies. The study includes two randomized controlled trials that aim to determine if this combined approach can reduce the risk of cancer while allowing women to maintain their fertility. By addressing both the hormonal and weight-related factors contributing to endometrial hyperplasia, the research seeks to provide a more acceptable treatment option for women who wish to avoid hysterectomy. Participants will be monitored for their response to the treatment and any changes in their health outcomes.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for women at risk of endometrial cancer, allowing them to preserve their fertility.
How similar studies have gone: Previous research has shown that weight loss can reverse atypical endometrial hyperplasia, suggesting that this combined approach may be promising.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Hagemann, Andrea — Washington University
- Study coordinator: Hagemann, Andrea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.