Preventing early substance use in American Indian youth and supporting families

Evaluation of an optimized intervention to prevent early substance use among American Indian youth: Examination of expanded impacts on youth and parents

NIH-funded research University of Colorado Denver · NIH-11248730

A culturally grounded program that strengthens family, cultural, and community ties to help American Indian adolescents avoid starting alcohol and drug use.

Quick facts

Grant typeR37 grant
Study typeNIH-funded research
Funding institutionUniversity of Colorado Denver NIH-funded
Lab location1 site (Aurora, UNITED STATES)
Project IDNIH-11248730 on NIH RePORTER

What this research studies

You would be invited to take part in Thiwáhe Gluwáš’akapi (TG), a prevention program co-developed with a Northern Plains Reservation that brings together young American Indian adolescents and their parents to build family and cultural connections. The research team refined the program through a multiphase optimization trial (TG1) and is now testing the optimized version in a larger, community-based effort. Participation typically involves attending group sessions, completing brief surveys, and allowing follow-up contacts to see how youth and parent outcomes change over time. The project is run in partnership with tribal communities to keep the program culturally relevant and locally led.

Who could benefit from this research

Good fit: Ideal candidates are American Indian adolescents (early teens) and their parents or caregivers from partnering tribal communities, especially those on the Northern Plains Reservation.

Not a fit: This preventive program is unlikely to help people who already have an established substance use disorder or those who are not within the targeted tribal communities or age range.

Why it matters

Potential benefit: If successful, the program could reduce early substance use among American Indian adolescents and strengthen protective family and cultural supports.

How similar studies have performed: Earlier pilot and optimization work (TG1) showed promising preliminary results, but larger community trials are ongoing to confirm the effects.

Where this research is happening

Aurora, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.