Preventing damage at telomeres to enhance cancer treatment effectiveness
Neutralizing oxidative damage at telomeres prevents T cell dysfunction and improves adoptive cell therapies against cancer
['FUNDING_R21'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11034627
This study is looking at how damage to the ends of chromosomes in immune cells affects their ability to fight cancer in patients receiving special treatments, with the goal of finding ways to help these cells work better and last longer in the body.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11034627 on ClinicalTrials.gov |
What this research studies
This research investigates how oxidative damage at telomeres affects T cell function in cancer patients undergoing adoptive cell therapies. By understanding the role of reactive oxidative species in the tumor microenvironment, the study aims to improve the persistence and effectiveness of T cells in fighting tumors. The approach involves analyzing telomere integrity in immune cells and exploring methods to neutralize oxidative stress, potentially leading to better outcomes for patients receiving these therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are receiving or are eligible for adoptive cell therapies.
Not a fit: Patients who are not undergoing adoptive cell therapies or those with conditions unrelated to T cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved effectiveness of adoptive cell therapies, resulting in better cancer treatment outcomes for patients.
How similar studies have performed: Other research has shown promising results in enhancing immune responses through metabolic reprogramming, indicating that this approach may hold significant potential.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RIVADENEIRA, DAYANA — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: RIVADENEIRA, DAYANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.