Preventing congenital CMV transmission with vaccines
Efficacy of CMV vFcR vaccines to prevent congenital CMV transmission
This study is looking at a vaccine that could help prevent the spread of a virus called cytomegalovirus from pregnant mothers to their babies, especially for women who haven't been infected before, and it uses animal models to find out how to make the vaccine work better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10874240 on NIH RePORTER |
What this research studies
This research investigates the use of a vaccine to prevent congenital cytomegalovirus (cCMV) transmission from mother to fetus during pregnancy. It focuses on understanding how maternal immunity can be enhanced through vaccination, particularly in women who have not previously been infected with CMV. The study utilizes animal models to explore the immune response and the mechanisms by which the virus evades the immune system, aiming to develop a more effective vaccine strategy. By analyzing the immune response in pregnant rhesus macaques, the research seeks to identify ways to improve vaccine efficacy against cCMV.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant women, particularly those who have not been previously infected with CMV.
Not a fit: Patients who are not pregnant or who have already been infected with CMV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of congenital CMV infections, leading to better health outcomes for newborns.
How similar studies have performed: Previous research has shown promise in vaccine development for CMV, but this approach utilizing vFcR technology is relatively novel.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Permar, Sallie R. — Weill Medical Coll of Cornell Univ
- Study coordinator: Permar, Sallie R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.