Preventing cholera in children with a single dose of azithromycin
Single dose azithromycin to prevent cholera in children
This project is looking at whether a single dose of azithromycin can help protect young children from getting cholera.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11093936 on NIH RePORTER |
What this research studies
Cholera is a serious illness that affects many people, especially young children who aren't fully protected by current vaccines. This project aims to find better ways to prevent cholera in these vulnerable children. Researchers are testing if a single dose of the antibiotic azithromycin can effectively stop children from getting cholera. This work is important because there are currently no clear guidelines for using antibiotics to prevent cholera, and finding an effective method could save many lives.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be young children, aged 0-11 years old, living in areas where cholera is common.
Not a fit: Patients outside the 0-11 age range or those not at risk of cholera exposure would likely not receive direct benefit from this specific prevention strategy.
Why it matters
Potential benefit: If successful, this approach could provide a simple and effective way to protect young children from cholera, potentially saving many lives and reducing the spread of the disease.
How similar studies have performed: While antibiotics are used to treat cholera, there are currently no established standards or proven approaches for using antibiotics specifically to prevent cholera, making this a novel area of investigation.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Harris, Jason B — Massachusetts General Hospital
- Study coordinator: Harris, Jason B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.