Preventing cervical cancer in women with HPV and HIV in India
Secondary Cervical Cancer Prevention of Vulnerable Women with HPV and HIV Co-infection in India
This project offers HPV screening plus emotional support, nutrition education, and protein supplements to women living with HIV and HPV in India to help lower cervical precancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11401650 on NIH RePORTER |
What this research studies
You would be offered regular HPV screening and cervical exams alongside counseling, social support, and nutrition help delivered by community health workers (ASHA) and nurses. The program compares women who receive the combined ASHA-nurse support and protein supplementation with those receiving usual care, with active follow-up over time. Study staff will monitor cervical screening results, immune (CD4) counts, body composition, and mental health to see whether the combined approach reduces precancerous cervical lesions. This work builds on a prior trial of 600 women that showed improved CD4 counts, lean mass, and mental health with the ASHA-Nutrition approach.
Who could benefit from this research
Good fit: Women in India living with HIV who are eligible for HPV screening, able to attend local clinic visits, and willing to receive counseling and nutritional supplementation are the ideal candidates.
Not a fit: People without HIV, those who cannot travel to participating clinics, or those who decline the screening, counseling, or supplementation may not benefit from this program.
Why it matters
Potential benefit: If successful, the approach could reduce the development of cervical precancers and ultimately lower cervical cancer risk among women living with HIV by improving screening, nutrition, and immune health.
How similar studies have performed: The same team’s prior trial showed improved CD4 counts, lean mass, and mental health with this intervention, but direct prevention of cervical cancer remains to be demonstrated.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Nyamathi, Adeline M — University of California-Irvine
- Study coordinator: Nyamathi, Adeline M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.