Preventing cancer spread in breast cancer patients after treatment.
Official title: Targeting the HMGB1-TLR5 pathway to prevent senescence-induced metastasis in breast cancer.
Funded at New York University School of Medicine · NIH-10877893 · Data updated 2026-11-12
This study is looking at how some breast cancer treatments, like chemotherapy, might accidentally help cancer cells spread, and it aims to find ways to stop this from happening so that patients can have better outcomes after their initial treatment.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $84,750 |
| NIH project number | 5R03CA269552-02 |
| Project ID | NIH-10877893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are breast cancer patients undergoing chemotherapy or radiotherapy who are at risk of metastasis.
✕Less likely to help
Patients with non-breast cancers or those not receiving chemotherapy or radiotherapy may not benefit from this research.
What this research studies
This research investigates how certain treatments for breast cancer, like chemotherapy, can unintentionally lead to the spread of cancer cells. It focuses on understanding the biological processes that occur when cancer cells and surrounding healthy cells respond to treatment, particularly how they can become more aggressive. By targeting specific pathways involved in this process, the research aims to develop strategies to prevent the spread of cancer after initial treatment, potentially improving patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the spread of breast cancer after chemotherapy, improving survival rates.
How similar studies have gone: Other research has shown promise in targeting similar pathways to reduce cancer metastasis, indicating that this approach may be effective.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: David, Gregory — New York University School of Medicine
- Study coordinator: David, Gregory
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.