Preventing breast cancer related to childbirth
Official title: Targeted Prevention of Postpartum-Related Breast Cancer (PRBC)
Funded at Mayo Clinic Jacksonville · NIH-11042754 · Data updated 2026-11-12
This study is looking at how having a baby might raise the risk of breast cancer in women within five years after childbirth, and it’s exploring whether certain anti-inflammatory medications could help lower that risk by examining changes in breast tissue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $650,300 |
| NIH project number | 5R01CA262393-04 |
| Project ID | NIH-11042754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have recently given birth and have a family history of breast cancer or other risk factors.
✕Less likely to help
Patients who are not postpartum or do not have risk factors for breast cancer may not benefit from this research.
What this research studies
This research investigates the increased risk of breast cancer that can occur in women within five years after giving birth. It focuses on understanding how postpartum changes in breast tissue, particularly inflammation, may contribute to this risk. The study aims to explore the potential preventive effects of non-steroidal anti-inflammatory drugs (NSAIDs) in women who are at higher risk for postpartum-related breast cancer. By analyzing breast tissue samples and patient histories, the research seeks to identify biomarkers that could help predict and prevent breast cancer in this population.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies for women at risk of postpartum-related breast cancer.
How similar studies have gone: Previous research has indicated that NSAIDs may reduce breast cancer risk in women with benign breast disease, suggesting a promising avenue for this study.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Sherman, Mark E — Mayo Clinic Jacksonville
- Study coordinator: Sherman, Mark E
Related research
Other NIH-funded projects on the same topics.
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Pregnancy, breastfeeding, and immune changes in postpartum breast cancer
This research tests whether breast changes after pregnancy make postpartum breast cancer more aggressive and whether breastfeeding or common anti-inflammatory medicines might lower that risk for women who recently gave birth.
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Preventing breast cancer in the years after childbirth
This project tries to prevent breast cancer that appears within five years after giving birth by studying whether common anti-inflammatory drugs like aspirin can lower that risk for women who recently had a baby or have benign breast disease.
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How immune cells and lymphatic changes after childbirth affect postpartum breast cancer
This project looks at how immune cells and lymphatic changes in the breast after childbirth may make postpartum breast cancers more likely to grow and spread, especially in women who did not breastfeed or stopped early.
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Investigating how the environment around tumors affects breast cancer after pregnancy
This study is looking at how breast cancer that happens after having a baby might be different and more serious, and it aims to find ways to help young women who face this challenge by understanding what happens in the tumor environment during this time.
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Investigating how the environment around tumors affects breast cancer after pregnancy
This study is looking at how pregnancy might change the way breast cancer behaves, especially for new moms, to find ways to lower the risk and improve treatment for those who develop postpartum breast cancer.
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Wearable tech to track blood loss during childbirth
A wearable device monitors cardiovascular signals to detect postpartum hemorrhage early so clinicians can act quickly to protect mothers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.