Preventing and treating nerve damage caused by chemotherapy
Prevention and treatment of paclitaxel-induced peripheral neuropathy
['FUNDING_R21'] · UNIVERSITY OF ROCHESTER · NIH-10755336
This study is looking at whether a medication called 4-aminopyridine can help relieve the painful nerve issues that many cancer patients experience from chemotherapy, with the hope of making their lives a little easier during treatment.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-10755336 on ClinicalTrials.gov |
What this research studies
This research focuses on chemotherapy-induced peripheral neuropathy (CIPN), a painful condition affecting many cancer patients undergoing treatment. The study aims to evaluate the effectiveness of 4-aminopyridine (4AP), a drug that may help prevent or alleviate the symptoms of CIPN. By restoring normal nerve function, the research seeks to improve the quality of life for patients and reduce the financial burden associated with CIPN. The approach involves clinical trials to assess the safety and efficacy of 4AP in this context.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients receiving chemotherapy who are at risk of developing peripheral neuropathy.
Not a fit: Patients who are not undergoing chemotherapy or those who have pre-existing neuropathy unrelated to chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for cancer patients by reducing or preventing nerve damage caused by chemotherapy.
How similar studies have performed: Previous studies have shown promise in using 4-aminopyridine for nerve-related conditions, indicating potential for success in this novel application.
Where this research is happening
ROCHESTER, UNITED STATES
- UNIVERSITY OF ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NOBLE, MARK D — UNIVERSITY OF ROCHESTER
- Study coordinator: NOBLE, MARK D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer