Preventing and Reversing Interstitial Fibrosis in HFpEF
Funded at VA Western New York Healthcare System · NIH-11398694 · Data updated 2026-11-12
Aimed at aging veterans, this effort seeks to understand and tackle the heart condition HFpEF by studying how fibrosis and inflammation contribute to heart failure with preserved ejection fraction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Western New York Healthcare System NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | January 1, 2016 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| NIH project number | 5I01BX002659-12 |
| Project ID | NIH-11398694 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with or at risk for HFpEF, especially older individuals with comorbidities such as obesity, diabetes, COPD, or hypertension, may benefit from future translational findings.
✕Less likely to help
This grant involves preclinical animal studies; direct benefits may not be immediate for patients until later translational work.
What this research studies
HFpEF is a common type of heart failure in older adults and is not well understood. This grant focuses on developing and using animal models to study how inflammation, microvascular dysfunction, and fibrosis contribute to HFpEF's progression. By addressing gaps in current models, the project hopes to reveal mechanisms that could lead to new treatments tailored for patients with HFpEF. The work is centered on translating findings from animal studies to human disease and may illuminate potential therapeutic targets for improving heart function in affected individuals.
Why it matters
Potential benefit: If successful, the research could identify new ways to prevent or reverse fibrosis in HFpEF, potentially improving symptoms and quality of life for patients.
How similar studies have gone: Previous animal-model approaches have informed understanding of HFpEF, but current models may not fully replicate human disease, making this work both informed by prior findings and exploring new avenues.
Where this research is happening
-
VA Western New York Healthcare System
Buffalo, United States Active
Researchers
- Principal investigator: Weil, Brian Raymond — VA Western New York Healthcare System
- Study coordinator: Weil, Brian Raymond
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.