Preventing Alzheimer’s-like brain changes in people with HIV by targeting a specific receptor
Official title: PREVENTING ALZHEIMER’S DISEASE-LIKE BRAIN PATHOLOGY IN HIV INFECTION BY TARGETING CCR5
Funded at University of Nebraska Medical Center · NIH-11013426 · Data updated 2026-11-12
This study is looking at how HIV might cause brain changes similar to those seen in Alzheimer’s disease, and it’s for people living with HIV who want to understand how their condition could affect their brain health and how treatments might help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | April 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $587,137 |
| NIH project number | 5R01MH132517-03 |
| Project ID | NIH-11013426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who may be experiencing cognitive decline or neurocognitive disorders.
✕Less likely to help
Patients who do not have HIV or those who are not experiencing any cognitive issues may not benefit from this research.
What this research studies
This research investigates how HIV infection may lead to Alzheimer’s disease-like brain changes, including the buildup of harmful proteins and neuroinflammation. The study aims to understand the mechanisms behind these changes and how antiretroviral therapy may influence them. By examining brain tissues from individuals living with HIV, the researchers will explore the role of specific receptors and enzymes in the production of amyloid-beta and tau proteins, which are associated with neurodegeneration. The approach includes laboratory experiments using humanized mice to model these processes and test potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or mitigating Alzheimer’s disease-like symptoms in people living with HIV.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between HIV and Alzheimer’s-like pathology, suggesting that this research builds on established findings.
Where this research is happening
-
University of Nebraska Medical Center
Omaha, United States Active
Researchers
- Principal investigator: Kanmogne, Georgette D. — University of Nebraska Medical Center
- Study coordinator: Kanmogne, Georgette D.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.