Preventing Alzheimer's Disease in individuals with Down Syndrome
Clinical trials to prevent Alzheimer's Disease in Down Syndrome
This study is looking for ways to help prevent Alzheimer's Disease in adults with Down Syndrome by testing new treatments that target a specific process in the brain, and it's designed for people with Down Syndrome who want to be part of this important research.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10913313 on NIH RePORTER |
What this research studies
This research focuses on conducting clinical trials aimed at preventing Alzheimer's Disease (AD) in adults with Down Syndrome (DS). Given that individuals with DS have a significantly higher risk of developing AD, the study aims to explore the effects of manipulating the amyloid pathway, which is linked to AD progression. The trials will be conducted through a network of specialized sites that have expertise in both Alzheimer's and Down Syndrome, utilizing established collaborations to ensure comprehensive care and data collection. Participants will be monitored for changes in biomarkers and cognitive function as part of the trial.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down Syndrome who are at risk for developing Alzheimer's Disease.
Not a fit: Patients without Down Syndrome or those who are not at risk for Alzheimer's Disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to effective strategies for preventing or delaying the onset of Alzheimer's Disease in individuals with Down Syndrome.
How similar studies have performed: Previous research has shown promising results in targeting amyloid pathways in Alzheimer's Disease, making this approach both relevant and potentially impactful.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Rafii, Michael S — University of Southern California
- Study coordinator: Rafii, Michael S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.