Preventing age-related blood clots
Preventive mechanisms of Age-associated Thrombosis
Testing whether calorie restriction and drugs that boost mitochondrial defenses can lower dangerous blood clot risk in older adults and people with type 2 diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11251585 on NIH RePORTER |
What this research studies
This project looks at why older people and people with type 2 diabetes form dangerous blood clots more easily, and what might stop that from happening. Researchers will use experiments in aged mice (including mice with diabetes) and lab tests on human platelets to see how calorie restriction and molecules that boost mitochondrial health affect clotting. They are especially focused on mitochondrial proteins like SIRT3 and SOD2 that control oxidative stress inside platelets. The team aims to find a druggable target that could lead to treatments to prevent heart attacks, strokes, and deep vein clots linked to aging.
Who could benefit from this research
Good fit: Older adults, particularly those with type 2 diabetes or obesity, or people willing to give blood samples for platelet testing, would be the most relevant candidates.
Not a fit: Younger patients or people whose clotting problems come from unrelated genetic disorders or currently well-controlled non-age-related causes may be unlikely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent heart attacks, strokes, and deep vein thrombosis in older adults and people with type 2 diabetes.
How similar studies have performed: Early lab and animal studies suggest targeting mitochondrial stress (for example by boosting SIRT3 or mimicking SOD2) can reduce platelet activation, but translating these findings into human prevention approaches remains largely unproven.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Dayal, Sanjana — University of Iowa
- Study coordinator: Dayal, Sanjana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.