Preventing adult mental health problems by supporting children with genetic risk, financial strain, and social stress

Preventing Adult Mental Health Problems from Early Childhood in the Contexts of Genetic Susceptibility, Financial Strain, and Societal Stressors

NIH-funded research Oregon Research Institute · NIH-11285143

This project looks at whether early family support and life circumstances shape mental health in young adults who grew up in low-income households, especially when genetics or financial stress raise risk.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionOregon Research Institute NIH-funded
Lab location1 site (Springfield, UNITED STATES)
Project IDNIH-11285143 on NIH RePORTER

What this research studies

If you were part of this work, you'd be included in the Early Steps Multisite group of 731 families recruited as toddlers from WIC centers and followed into adolescence and emerging adulthood. Half the families received a parenting support program called the Family Check-Up from age 2 to 10.5, and researchers collected surveys, neighborhood information, and genetic samples with follow-ups at ages 14, 16, and 19. Researchers will use those long-term data to link early intervention, family and neighborhood stressors, and genetic risk to mental health outcomes like anxiety, depression, suicidality, and psychosis in emerging adults. The goal is to figure out who benefits most from early supports so future programs can better prevent adult mental health problems.

Who could benefit from this research

Good fit: This work is most relevant to emerging adults who grew up in low-income families—especially those who participated in the Early Steps study or who have early-childhood and genetic information available.

Not a fit: People without early-childhood records, genetic data, or whose mental health issues began solely in later life may not directly benefit from the study's findings.

Why it matters

Potential benefit: If successful, the project could show which early family supports and social policies best reduce anxiety, depression, suicidal behavior, and psychosis in people who grew up with financial strain.

How similar studies have performed: Previous trials of the Family Check-Up and similar early parenting programs have reduced behavior problems and improved later mental health in some groups, but combining long-term clinical outcomes with genetics and neighborhood data is relatively new.

Where this research is happening

Springfield, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.