PREVENTABLE — using a moderate‑intensity statin to prevent dementia in older adults
PREVENTABLE Administrative and Trial Management
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-11179145
This project gives adults 75 and older who do not have known heart disease a moderate‑intensity statin to see whether it lowers their chance of dementia and helps them stay independent longer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11179145 on ClinicalTrials.gov |
What this research studies
You would join a large, multi‑center effort led by Duke and Wake Forest that enrolls people age 75 and up without clear coronary heart disease and assigns some participants to a moderate‑intensity statin while others receive usual care, then follows everyone for dementia and disability outcomes. The trial is pragmatic and designed to fit into routine care by using electronic health records, streamlined electronic consent, and partnerships with health networks to simplify participation. People with frailty, mild cognitive impairment, multiple medicines, or several chronic conditions are included so the results apply to typical older adults. Investigators will track diagnoses of Alzheimer’s disease and related dementias and measure years lived free of disability over several years.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 75 or older without clinically evident coronary heart disease, including those with frailty, impaired physical function, mild cognitive impairment, polypharmacy, or multiple chronic conditions.
Not a fit: People younger than 75, those with known coronary heart disease, those already taking high‑intensity statins, or those with medical contraindications to statins may not be eligible or benefit.
Why it matters
Potential benefit: If successful, this approach could lower dementia risk and increase the time older adults live without disability.
How similar studies have performed: Prior trials and observational studies of statins and dementia have shown mixed or inconclusive results, making this large pragmatic trial in older adults a relatively novel effort to provide clearer evidence.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALEXANDER, KAREN P — DUKE UNIVERSITY
- Study coordinator: ALEXANDER, KAREN P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia