PREVENTABLE sample bank for people 75 and older
PREVENTABLE Biorepository and Laboratory
This project collects and stores blood and other samples from people 75 and older without known coronary heart disease who are taking a moderate-intensity statin to see whether it helps prevent dementia and prolong disability-free survival.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11179166 on NIH RePORTER |
What this research studies
If I join, the study will collect blood and other samples from me and store them at the Mayo Clinic Biorepository. Researchers will use these samples to check statin effects (for example, changes in cholesterol), look for biological markers that show who benefits most, and study how heart and brain health are connected. The biobank will include about 17,000 PREVENTABLE participants, including people with frailty or mild cognitive impairment. My samples may be shared with approved scientists for future research, though I might not get direct results back.
Who could benefit from this research
Good fit: People aged 75 and older without clinically evident coronary heart disease, including those with frailty, impaired physical function, or mild cognitive impairment, are the intended participants.
Not a fit: You likely would not receive benefit if you are under 75, have known coronary heart disease, or are not enrolled in the PREVENTABLE trial.
Why it matters
Potential benefit: If successful, this could show whether statins lower the risk of dementia in older adults and help tailor prevention to the people most likely to benefit.
How similar studies have performed: Previous studies of statins for dementia prevention have produced mixed and inconclusive results, so this large trial and biobank are intended to provide clearer answers.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Newby, Laura Kristin — Duke University
- Study coordinator: Newby, Laura Kristin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.