PREVENTABLE coordinating center for using statins to protect memory in older adults
PREVENTABLE Data Coordinating Center
This project supports giving a moderate-intensity statin to people aged 75 and older to try to lower the chance of dementia and help them live longer without disability.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11179151 on NIH RePORTER |
What this research studies
From a patient's view, this team runs the data and operations behind the PREVENTABLE trial that compares a moderate-dose statin to usual care in adults 75 and older. They will work with clinics across the United States to enroll people, track health and cognitive outcomes, and make sure follow-up visits and medication adherence are done well. The coordinating center will also monitor safety, report data to the study safety board, and support the trial statisticians who analyze results. The trial intentionally includes older adults with frailty, reduced physical function, mild cognitive impairment, multiple medical conditions, and those on several medicines.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 75 and older without known coronary heart disease, including those with mild cognitive impairment, frailty, reduced physical function, or multiple chronic conditions.
Not a fit: People younger than 75, those already taking a statin for heart disease, or those who cannot safely take statins are unlikely to benefit from this trial.
Why it matters
Potential benefit: If successful, the effort could reduce new cases of dementia and increase years lived free of disability among people 75 and older.
How similar studies have performed: Prior research on statins preventing dementia has been mixed and large randomized trials in very old adults are limited, so this effort addresses an important evidence gap.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Hammill, Bradley G — Duke University
- Study coordinator: Hammill, Bradley G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.