Preparing for preventive trials in Huntington's disease
Preparing for preventive clinical trials in Huntington's disease
['FUNDING_U01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11195121
This study is looking at Huntington's disease before symptoms show up, using information from over 1,400 volunteers who have had genetic testing, to find better ways to track how the disease progresses and see if new treatments work, by testing a new method that measures a specific protein in the fluid around the brain that could help predict how the disease will develop.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11195121 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding Huntington's disease (HD) before symptoms appear, using data from over 1400 volunteers who have undergone genetic testing. It aims to develop reliable measures for tracking disease progression and assessing the effectiveness of potential treatments. The study will investigate the reliability of a new assay that measures mutant huntingtin protein in the cerebrospinal fluid, which could help predict disease outcomes and inform clinical trials. By addressing key questions about this assay's validity and reliability, the research seeks to enhance the design of future preventive clinical trials.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have undergone genetic testing for Huntington's disease and are currently asymptomatic.
Not a fit: Patients who are already diagnosed with symptomatic Huntington's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective preventive treatments for Huntington's disease, potentially delaying its onset or slowing its progression.
How similar studies have performed: Previous research has shown promise in similar approaches, particularly in tracking disease progression and developing preventive strategies for neurodegenerative diseases.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PAULSEN, JANE S — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: PAULSEN, JANE S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.