Predicting which children are at risk for ongoing health and school problems after a concussion
A Risk Stratification Model for Health and Academic Outcomes in Children with Concussion Based on Novel Symptom Trajectory Typologies
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11301804
The team will use patterns of symptoms and biological signs to predict which children with a recent concussion are likely to have longer-lasting health and school difficulties.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11301804 on ClinicalTrials.gov |
What this research studies
If your child has a concussion, researchers will follow their symptoms over time and collect information about fatigue, mood, and thinking problems. They will also measure biological markers linked to inflammation from blood samples to see how those markers relate to symptom paths. The study combines symptom trajectories, lab results, and school attendance/performance to build a model that flags kids at higher risk for persistent problems. Participants will have regular check-ins, surveys, and clinic visits during the follow-up period so clinicians can identify needs earlier.
Who could benefit from this research
Good fit: School-aged children who recently experienced a concussion and can attend follow-up visits at the study site are ideal candidates.
Not a fit: Adults, people without a concussion, or children whose concussion occurred long ago may not be eligible or benefit directly from this work.
Why it matters
Potential benefit: If successful, this could help identify children at high risk earlier so they get targeted care and school support to reduce long-term symptoms and missed class time.
How similar studies have performed: Previous work has linked inflammatory markers to post-concussion symptoms, but using longitudinal symptom patterns to build pediatric risk models is relatively new.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REUTER-RICE, KARIN — DUKE UNIVERSITY
- Study coordinator: REUTER-RICE, KARIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury