Predicting when a common heart condition in premature infants will close on its own
Early Prediction of Spontaneous Patent Ductus Arteriosus (PDA) Closure and PDA-Associated Outcomes
This study is looking at ways to help doctors figure out which premature babies with a heart condition called patent ductus arteriosus (PDA) might need treatment and which ones can get better on their own, so they can make safer choices for your little one.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10521258 on NIH RePORTER |
What this research studies
This research investigates how to identify premature infants with patent ductus arteriosus (PDA) who are at risk for complications. By analyzing clinical risk factors, echocardiogram measurements, and serum biomarkers, the study aims to predict which infants will benefit from treatment and which will close their PDA naturally. The goal is to improve decision-making for clinicians regarding PDA management, potentially reducing unnecessary treatments and associated risks for infants. The research involves a prospective cohort of untreated infants to gather data on PDA closure outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are premature infants diagnosed with patent ductus arteriosus.
Not a fit: Patients who are not premature or do not have a diagnosis of patent ductus arteriosus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better-targeted treatments for premature infants with PDA, improving their long-term health outcomes.
How similar studies have performed: Previous research has shown promise in using clinical indicators to predict outcomes in similar patient populations, suggesting that this approach may yield valuable insights.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Slaughter, Jonathan Lee — Research Inst Nationwide Children's Hosp
- Study coordinator: Slaughter, Jonathan Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.