Predicting the risk of endometriosis and its long-term health effects
Official title: Integrative risk modeling for early prediction of endometriosis and its long-term health outcomes
Funded at University of Pennsylvania · NIH-11053494 · Data updated 2026-11-12
This study is looking for ways to help women, especially those at higher risk, find out if they might develop endometriosis in the future, using simple tests that consider their genes and other factors, so they can get diagnosed earlier and receive better care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 15, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $654,633 |
| NIH project number | 5R01HD110567-03 |
| Project ID | NIH-11053494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include women of childbearing age who are experiencing symptoms suggestive of endometriosis or have a family history of the condition.
✕Less likely to help
Patients who are not at risk for endometriosis or those who have already been diagnosed and treated may not benefit from this research.
What this research studies
This research aims to develop effective and non-invasive tools to predict the risk of developing endometriosis in women, particularly those who are at higher risk due to genetic and environmental factors. By integrating various risk factors, including genomic markers and inflammatory indicators, the project seeks to identify patients who may develop endometriosis and its associated long-term health outcomes. The goal is to enable earlier diagnosis and preventive measures, ultimately improving patient care and outcomes. The research will involve creating models that assess individual risk profiles based on clinical manifestations and other relevant data.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and better management of endometriosis, reducing the time to treatment and improving long-term health outcomes for affected women.
How similar studies have gone: Other research has shown promise in using integrative risk models for predicting various health conditions, suggesting that this approach could be effective for endometriosis as well.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Verma, Shefali Setia — University of Pennsylvania
- Study coordinator: Verma, Shefali Setia
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.