Predicting the progression of sleep behavior disorders to neurodegenerative diseases
Project: Predicting Phenoconversion
This study is looking at how having REM sleep behavior disorder might be an early sign of conditions like Parkinson's disease and dementia, and it's for people with RBD who want to help researchers find ways to catch these diseases earlier and improve treatment options.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10866395 on NIH RePORTER |
What this research studies
This research investigates how rapid eye movement (REM) sleep behavior disorder (RBD) may indicate the early stages of neurodegenerative diseases like Parkinson's disease and dementia with Lewy bodies. By studying over 300 participants with RBD and matched controls, the project aims to collect and analyze clinical data, blood and cerebrospinal fluid samples, sleep studies, and neuroimaging results. The goal is to understand the progression from RBD to more severe conditions, which could lead to earlier interventions and treatments for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 50 who have been diagnosed with rapid eye movement sleep behavior disorder.
Not a fit: Patients without REM sleep behavior disorder or those with advanced neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable earlier diagnosis and treatment options for patients at risk of developing neurodegenerative diseases.
How similar studies have performed: Previous studies have shown promising results in understanding the link between REM sleep behavior disorder and neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Postuma, Ronald — Washington University
- Study coordinator: Postuma, Ronald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.