Predicting tau protein levels in Alzheimer's disease over time
Longitudinal predictive modeling for tau in Alzheimer's disease
This study is looking at how tau protein tangles, which can affect memory in Alzheimer's, form over time, and it aims to help predict who might be at risk for Alzheimer's by using special imaging techniques to track changes in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11085273 on NIH RePORTER |
What this research studies
This research focuses on understanding how tau protein tangles, which are linked to memory impairment in Alzheimer's disease, develop over time. By using advanced imaging techniques and machine learning, the study aims to create personalized predictions of tau burden based on individual brain connectivity patterns. Patients will be monitored through longitudinal imaging to track changes in tau levels, which could help identify those at risk for Alzheimer's before symptoms appear. The goal is to improve early diagnosis and treatment strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be at risk for Alzheimer's disease, particularly those with early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of Alzheimer's disease, potentially improving patient outcomes.
How similar studies have performed: Previous studies have shown promise in using imaging and machine learning to predict Alzheimer's progression, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dutta, Joyita — Massachusetts General Hospital
- Study coordinator: Dutta, Joyita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.