Predicting sudden dangerous heart rhythms in people with coronary artery disease and mildly reduced heart function
PRE-DETERMINE: Advancing Sudden Arrhythmic Death Prediction in Coronary Artery Disease in the Absence of Severe Systolic Dysfunction
This project will find better ways to spot which people with coronary artery disease and moderately preserved heart pumping are at risk for sudden, deadly heart rhythms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11261237 on NIH RePORTER |
What this research studies
Researchers will continue following a long-term group of people with coronary artery disease whose heart pumping (LVEF) is above the usual ICD cutoff, tracking deaths and dangerous ventricular arrhythmias over 10+ years. The team will collect clinical information, blood tests, and biological markers, and will use standardized review of events to determine causes of death. They will analyze these data to build and refine risk models that could identify people who might benefit from preventive therapies like implantable defibrillators. Participation typically involves medical record review, periodic follow-up visits, and blood draws.
Who could benefit from this research
Good fit: Ideal candidates are people with coronary artery disease whose left ventricular ejection fraction is above roughly 30–35% and who can take part in long-term follow-up and testing.
Not a fit: People who already have severely reduced LVEF below the ICD threshold or who do not have coronary artery disease are unlikely to benefit from this specific study.
Why it matters
Potential benefit: If successful, this work could help doctors identify more patients who need life-saving defibrillators and reduce sudden cardiac deaths.
How similar studies have performed: Previous trials showed ICDs prevent sudden death in patients with very low LVEF, but few long-term prospective studies have tested risk prediction in people with LVEF above 30–35%, so this approach is building on limited prior evidence.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Albert, Christine M — Cedars-Sinai Medical Center
- Study coordinator: Albert, Christine M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.