Predicting side effects from prostate cancer radiation using advanced computer models
Multi-cohort validation of machine learning radiogenomic models (ML-RGx) to predict late toxicity in prostate cancer
['FUNDING_R01'] · MEDICAL COLLEGE OF WISCONSIN · NIH-11112405
This project aims to develop a better way to predict which prostate cancer patients might experience side effects from radiation therapy, helping doctors personalize treatment plans.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL COLLEGE OF WISCONSIN (nih funded) |
| Locations | 1 site (MILWAUKEE, UNITED STATES) |
| Trial ID | NIH-11112405 on ClinicalTrials.gov |
What this research studies
Radiation therapy is a common and effective treatment for prostate cancer, but it can sometimes lead to uncomfortable side effects in the bladder and rectum, impacting a patient's quality of life. While radiation exposure plays a role, individual genetic differences also influence who develops these side effects. This research uses a new machine learning approach that combines information from many genetic markers and radiation dose details to create a 'radiogenomic' risk score. The goal is to identify patients at higher risk of side effects before they even begin radiation therapy, allowing for more tailored care.
Who could benefit from this research
Good fit: This research is relevant for men who have been treated with radiation therapy for prostate cancer or are considering it.
Not a fit: Patients who have not received or are not candidates for radiation therapy for prostate cancer would not directly benefit from this specific prediction model.
Why it matters
Potential benefit: If successful, this work could help doctors identify patients at high risk for radiation side effects, allowing for adjustments to treatment or closer monitoring to improve quality of life.
How similar studies have performed: Preliminary data from this research team suggests their new modeling approach performs better than existing methods and shows promise for clinical use.
Where this research is happening
MILWAUKEE, UNITED STATES
- MEDICAL COLLEGE OF WISCONSIN — MILWAUKEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KERNS, SARAH L. — MEDICAL COLLEGE OF WISCONSIN
- Study coordinator: KERNS, SARAH L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.