Predicting short- and medium-term outcomes for hospitalized older adults with or without Alzheimer's disease
Prognostic Indices for Hospitalized Older Adults with and without Alzheimer’s Disease and Related Dementias
This project will build hospital-record tools to predict 6-month and 2-year survival for older adults hospitalized with or without Alzheimer's disease to help guide hospice, palliative care, and medication decisions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11111320 on NIH RePORTER |
What this research studies
If you are an older adult hospitalized with or without Alzheimer's-related dementia, researchers will use routine hospital records and documented functional status to build prediction tools that estimate 6-month and 2-year survival. The 6-month prediction is meant to help clinicians consider hospice, while the 2-year prediction is intended to support outpatient palliative care referrals and medication deprescribing. The team will create separate tools for people with Alzheimer's-related dementia and for those without, because decline often follows different paths. They will develop models using data from several hospitals and then test them on records from other hospitals to make sure the tools work broadly.
Who could benefit from this research
Good fit: Ideal candidates are older adults who are currently hospitalized and have electronic health records that include documented functional status, whether they have Alzheimer's-related dementia or not.
Not a fit: You may not benefit if you are not hospitalized, are younger than the populations included, or if your hospital does not record functional status in the electronic health record used by this project.
Why it matters
Potential benefit: If successful, these tools could help patients get timely hospice or palliative care and avoid unnecessary or harmful medications.
How similar studies have performed: Other prognostic tools using health records have shown promise for predicting short-term mortality, but developing separate, function-informed models specifically for people with and without dementia is relatively novel.
Where this research is happening
San Francisco, United States
- Northern California Institute/res/edu — San Francisco, United States (Active)
Researchers
- Principal investigator: Lee, Sei — Northern California Institute/res/edu
- Study coordinator: Lee, Sei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.