Predicting seizures after stroke with genetic risk scores
Polygenic Risk Scores (PRS) to Predict Post-Stroke Epilepsy (PSE) in the Million Veterans Program (MVP) Cohort
This project will create genetic risk scores to identify Veterans most likely to develop seizures after a stroke.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Portland VA Medical Center NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11053189 on NIH RePORTER |
What this research studies
This project uses genetic and medical records from the Million Veterans Program to build scores that predict who develops seizures after a stroke. Researchers will combine common genetic variants and rare pathogenic gene changes into a single risk model and compare that model to known clinical risk factors. They will estimate how often genetic testing would find useful results and how the scores could be added to tools clinicians use after stroke. The aim is to help guide who should get genetic testing or closer seizure monitoring after a stroke.
Who could benefit from this research
Good fit: Ideal candidates are people who have had a stroke — especially U.S. military Veterans enrolled in the Million Veterans Program — who are willing to share genetic and medical record data.
Not a fit: People without a prior stroke, non-Veterans who cannot join the Million Veterans Program, or those whose seizure risk is driven entirely by non-genetic factors may not benefit from this work.
Why it matters
Potential benefit: If successful, this could help target genetic testing and closer monitoring to stroke survivors at highest risk for seizures, potentially reducing preventable seizures and improving outcomes.
How similar studies have performed: Similar polygenic risk-score methods have shown promise for other forms of epilepsy and cardiovascular outcomes, but applying combined common-and-rare-variant models specifically to post-stroke epilepsy is new and not yet well tested.
Where this research is happening
Portland, United States
- Portland VA Medical Center — Portland, United States (Active)
Researchers
- Principal investigator: Kellogg, Marissa Anne — Portland VA Medical Center
- Study coordinator: Kellogg, Marissa Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.