Predicting risks and costs for people with cirrhosis
Natural history, risk prediction and cost of cirrhosis in insured Americans.
Using U.S. health insurance records to find which people with cirrhosis are most likely to have serious complications and how much their care costs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11018505 on NIH RePORTER |
What this research studies
Researchers will analyze a large national insurance database of insured Americans from 2011–2018 that includes diagnoses, procedures, lab tests, medications, inpatient and outpatient visits, and standardized costs. They will build and test models to identify patients likely to develop decompensating events such as ascites, hepatic encephalopathy, gastrointestinal bleeding, or liver cancer. The team will also quantify the long-term health care costs and cost drivers for people with cirrhosis. Findings aim to highlight who may need earlier guideline-recommended care or new therapies.
Who could benefit from this research
Good fit: People with a diagnosed diagnosis of cirrhosis whose care appears in U.S. health insurance claims (insured Americans) are the population represented by this work.
Not a fit: People without U.S. insurance, those whose care is not captured in insurance claims, or patients with scant recorded health-care use may not be represented and therefore may not directly benefit.
Why it matters
Potential benefit: This work could help clinicians spot high-risk patients sooner and target care to reduce hospitalizations, complications, and costs.
How similar studies have performed: Some prior prediction models exist but have not reliably identified who will decompensate, and comprehensive U.S.-level cost analyses for cirrhosis have been limited, so this work builds on prior models while filling an important gap.
Where this research is happening
Chicago, United States
- Northwestern University — Chicago, United States (Active)
Researchers
- Principal investigator: Ladner, Daniela P — Northwestern University
- Study coordinator: Ladner, Daniela P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.