Predicting risk in pulmonary arterial hypertension using genetics and long-term health data
Risk stratification in pulmonary arterial hypertension: Intersection of OMICs and longitudinal phenotypes through the PAH Biobank
This project combines genetic and other molecular data with long-term clinical records to give people with pulmonary arterial hypertension clearer information about their risk of worsening.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11184218 on NIH RePORTER |
What this research studies
The research team uses samples and medical records from the PAH Biobank to link DNA and other 'omics' data with what happens to patients over time. They will sequence genetic material and analyze other molecular signals, then match those findings to clinical measures and outcomes collected during follow-up. The goal is to find genetic markers and molecular patterns that signal faster disease progression or different responses to treatment. Promising markers will be checked across multiple cohorts to build better tools for predicting an individual's course of PAH.
Who could benefit from this research
Good fit: People diagnosed with idiopathic or heritable pulmonary arterial hypertension who can provide blood/tissue samples and allow use of their medical records, especially those enrolled in the PAH Biobank, are ideal candidates.
Not a fit: People without PAH or individuals who cannot or will not provide samples or medical information are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could help doctors identify people at higher risk sooner and personalize monitoring or treatment choices.
How similar studies have performed: Prior genetic studies have already identified loci (for example HLA-DPA1/DPB1 and SOX17) linked to PAH risk and survival, so this work builds on promising, but still-developing, evidence.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Nichols, William C — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Nichols, William C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.