Predicting protein function in eukaryotic parasites using advanced algorithms
Official title: A Structure-based orthology approach to predict protein function in eukaryotic parasites
Funded at Seattle Children's Hospital · NIH-11112406 · Data updated 2026-11-12
This study is looking at how certain proteins in parasites work, which could help us find new ways to treat infections that affect many people around the world.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 11, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $244,625 |
| NIH project number | 5R21AI182872-02 |
| Project ID | NIH-11112406 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by infectious diseases caused by eukaryotic parasites.
✕Less likely to help
Patients with non-infectious diseases or those not affected by eukaryotic parasites may not benefit from this research.
What this research studies
This research focuses on understanding the functions of proteins in eukaryotic parasites, which are responsible for various infectious diseases affecting millions globally. By utilizing advanced genome sequencing technologies and innovative algorithms, the project aims to accurately predict protein functions that have not been well characterized. The approach combines structural analysis with existing sequence data to enhance the annotation of proteins in a specialized database. This could lead to the identification of new therapeutic targets for treating infectious diseases.
Why it matters
Potential benefit: If successful, this research could significantly improve the understanding and treatment of infectious diseases caused by eukaryotic parasites.
How similar studies have gone: Other research has shown success in using structural approaches for protein function prediction, indicating a promising avenue for this novel methodology.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Phan, Isabelle — Seattle Children's Hospital
- Study coordinator: Phan, Isabelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.