Predicting pancreatic toxicity using advanced computational models
Official title: Integrating Computational and Experimental Models to Predict Toxicity of the Pancreas
Funded at San Diego State University · NIH-11015846 · Data updated 2026-11-12
This study looks at how different chemicals and environmental factors can affect the pancreas and diabetes, using zebrafish to help understand these effects better, with the hope of finding safer ways to protect pancreatic health for people with diabetes.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | February 15, 2023 |
| Project end | April 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $164,201 |
| NIH project number | 5R21DK134931-03 |
| Project ID | NIH-11015846 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with adult-onset diabetes, particularly those concerned about environmental influences on their health.
✕Less likely to help
Patients with diabetes that is solely attributed to genetic factors without environmental influences may not benefit from this research.
What this research studies
This research investigates how environmental factors and chemical structures affect pancreatic health, particularly in relation to diabetes. By utilizing advanced computational models and multilayer networks, the study aims to analyze the interactions between various biological factors and their impact on pancreatic toxicity. The research employs a zebrafish model to simulate and predict the effects of different chemicals on pancreatic development, which could lead to better understanding and prevention of diabetes. Patients may benefit from insights gained through this research that could inform safer environmental practices and treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and managing diabetes by understanding the environmental factors that contribute to pancreatic toxicity.
How similar studies have gone: Other research has shown promise in using computational models to understand disease mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
San Diego State University
San Diego, United States Active
Researchers
- Principal investigator: George, Uduak Zenas — San Diego State University
- Study coordinator: George, Uduak Zenas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.