Predicting outcomes for young people at high risk of psychosis
Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)
The team is creating tools that use clinical, brain, and biological data to predict how young people at high risk of psychosis will do over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Melbourne NIH-funded |
| Lab location | 1 site (Melbourne, Australia) |
| Project ID | NIH-11134618 on NIH RePORTER |
What this research studies
If you are a young person showing early or subthreshold psychotic symptoms, this project combines information from symptoms, thinking tests, brain scans, biological markers, and genetics to build prediction models. Researchers across a global consortium will pool and harmonize many patients' records and test different algorithms to identify who will develop psychosis, who will recover, and who will have ongoing problems. The project aims to turn those models into practical tools clinicians can use in early psychosis clinics. The goal is to help match people to the right care earlier and reduce long-term disability.
Who could benefit from this research
Good fit: Young people seen in early psychosis or clinical high risk services who are experiencing subthreshold psychotic symptoms, functional decline, or other early warning signs.
Not a fit: People without early warning signs, those with established long-term psychotic disorders, or individuals not connected to participating clinics may not directly benefit or be eligible.
Why it matters
Potential benefit: Could help clinicians identify individuals most likely to develop psychosis or poor outcomes so treatment can be targeted earlier and more precisely.
How similar studies have performed: Previous studies produced only modest prediction accuracy, so this larger, multimodal consortium effort is more comprehensive and aims to improve on past results.
Where this research is happening
Melbourne, Australia
- University of Melbourne — Melbourne, Australia (Active)
Researchers
- Principal investigator: Nelson, Christopher Barnaby — University of Melbourne
- Study coordinator: Nelson, Christopher Barnaby
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.