Predicting outcomes for young people at high risk for psychosis
Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)
['FUNDING_U01'] · UNIVERSITY OF MELBOURNE · NIH-11373905
This project will build tools to predict which young people with early warning signs of psychosis are likely to develop psychotic disorder or other lasting problems.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MELBOURNE (nih funded) |
| Locations | 1 site (MELBOURNE, AUSTRALIA) |
| Trial ID | NIH-11373905 on ClinicalTrials.gov |
What this research studies
You would join a global effort that combines clinical interviews, cognitive testing, brain imaging, biological markers, and genetic information from people identified as Clinical High Risk (CHR). Researchers will follow participants over time with active follow-up to see who develops psychosis, who recovers, and who has ongoing problems. They will use this multimodal data to train and validate prediction models and then turn those models into clinical tools. The aim is to give clinicians clearer information to guide early, targeted care.
Who could benefit from this research
Good fit: Ideal candidates are young people identified as Clinical High Risk for psychosis (subthreshold psychotic symptoms or recent functional decline) who can provide clinical, biological, and possibly imaging data and agree to follow-up visits.
Not a fit: People without CHR features or whose symptoms come from clearly non-psychotic causes would be unlikely to benefit directly from these specific prediction tools.
Why it matters
Potential benefit: If successful, clinicians could identify which at-risk young people need earlier or more intensive treatment to prevent psychosis or reduce long-term disability.
How similar studies have performed: Previous studies combining clinical, cognitive, imaging, and biological data have shown modest success in predicting outcomes, and this larger, multinational multimodal effort aims to improve that accuracy.
Where this research is happening
MELBOURNE, AUSTRALIA
- UNIVERSITY OF MELBOURNE — MELBOURNE, AUSTRALIA (ACTIVE)
Researchers
- Principal investigator: NELSON, CHRISTOPHER BARNABY — UNIVERSITY OF MELBOURNE
- Study coordinator: NELSON, CHRISTOPHER BARNABY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.