Predicting outcomes for people at high risk for psychosis
Trajectories and Predictors in the Clinical High Risk for Psychosis Population: Prediction Scientific Global Consortium (PRESCIENT)
['FUNDING_U01'] · UNIVERSITY OF MELBOURNE · NIH-11373938
This project will develop tools that use symptoms, thinking tests, brain scans, biological markers, and genetics to help predict future mental health outcomes for young people at high risk for psychosis.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MELBOURNE (nih funded) |
| Locations | 1 site (MELBOURNE, AUSTRALIA) |
| Trial ID | NIH-11373938 on ClinicalTrials.gov |
What this research studies
If you are worried you might be at high risk for psychosis, researchers will combine information from your symptoms, thinking tests, brain imaging, blood markers, and genes collected at clinics around the world. They will follow people over time to see who develops psychosis, who has ongoing non-psychotic disorders, who recovers, and who has lasting problems with daily functioning. Using these many kinds of data, the team will build prediction models and test them across different clinics to make sure they work for many people. The final goal is to turn the best models into simple, validated tools that clinicians can use to guide early care and personalized treatment.
Who could benefit from this research
Good fit: Young people identified as Clinical High Risk (CHR) for psychosis—those with recent subthreshold psychotic symptoms, functional decline, or other CHR indicators—are the ideal candidates.
Not a fit: People without CHR signs, those with an established psychotic disorder, or those unable to attend participating clinics or provide required tests may not benefit directly from this effort.
Why it matters
Potential benefit: If successful, the work could help clinicians identify who needs early, targeted care to prevent or reduce psychosis and improve daily functioning.
How similar studies have performed: Previous single-site studies have shown only modest success predicting psychosis, so this larger international consortium aims to improve accuracy by pooling diverse data.
Where this research is happening
MELBOURNE, AUSTRALIA
- UNIVERSITY OF MELBOURNE — MELBOURNE, AUSTRALIA (ACTIVE)
Researchers
- Principal investigator: NELSON, CHRISTOPHER BARNABY — UNIVERSITY OF MELBOURNE
- Study coordinator: NELSON, CHRISTOPHER BARNABY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.