Predicting oral HPV risk in people living with HIV using saliva-based biological and lifestyle markers
Multi-Omics Predictors of Oral HPV Outcomes among PLWH
Researchers will use saliva tests, oral microbiome and aging markers plus lifestyle information to find signs that predict oral HPV and whether it stays over time in adults living with HIV.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project ID | NIH-11171423 on NIH RePORTER |
What this research studies
You would be asked to provide saliva samples at two visits (baseline and six months) and answer questions about lifestyle and sexual practices. The team will analyze the germs in your mouth (oral microbiome), markers of biological aging in cells, and behavioral and socioeconomic data. They will combine these data with computer learning methods to build a tool that predicts who keeps HPV infection and who clears it. The study enrolls about 150 adults living with HIV who have suppressed virus on treatment.
Who could benefit from this research
Good fit: Adults aged 21 or older living with HIV who are on antiretroviral therapy with suppressed viral load are the ideal participants for this project.
Not a fit: People without HIV, people younger than 21, or those not on stable antiretroviral treatment are unlikely to be eligible or directly benefit from this study.
Why it matters
Potential benefit: If successful, this work could help spot people living with HIV who are at higher risk for persistent oral HPV so they can get closer monitoring or early prevention.
How similar studies have performed: Previous research has linked oral microbiome changes and aging markers to HPV and cancer risk, but combining multi-omics and machine learning to predict HPV persistence is a newer, less-tested approach.
Where this research is happening
San Juan, United States
- University of Puerto Rico Med Sciences — San Juan, United States (Active)
Researchers
- Principal investigator: Perez-Santiago, Josue — University of Puerto Rico Med Sciences
- Study coordinator: Perez-Santiago, Josue
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.