Predicting how peptides interact with other molecules.
Official title: Structure-based in-silico prediction of peptide interactions.
Funded at Scripps Research Institute, the · NIH-11037924 · Data updated 2026-11-12
This study is looking at how tiny proteins called peptides connect with other molecules in the body, which is important for healing, especially after brain injuries, and aims to create better tools to help scientists design new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $460,000 |
| NIH project number | 5R35GM152084-02 |
| Project ID | NIH-11037924 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced acquired brain injuries and may benefit from novel peptide-based therapies.
✕Less likely to help
Patients with conditions unrelated to peptide interactions or those who do not have acquired brain injuries may not receive any benefit from this research.
What this research studies
This research focuses on understanding the interactions between peptides and their binding partners, which are crucial for many cellular processes. By utilizing advanced computational methods, including physics-based and deep learning approaches, the team aims to enhance existing software for predicting these interactions. The goal is to expand the range of therapeutic peptides that can be synthesized and to improve the accuracy of peptide docking predictions. This work could lead to better-targeted treatments for conditions related to acquired brain injuries.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective therapeutic peptides for treating brain injuries and related conditions.
How similar studies have gone: Other research has shown success in using computational methods for predicting molecular interactions, indicating a promising avenue for this approach.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Sanner, Michel F. — Scripps Research Institute, the
- Study coordinator: Sanner, Michel F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.